D-CYCLOSERINE, A PUTATIVE COGNITIVE ENHANCER, FACILITATES ACTIVATION OF THE N-METHYL-D-ASPARTATE RECEPTOR IONOPHORE COMPLEX IN ALZHEIMER BRAIN

被引：57

作者：

CHESSELL, IP

PROCTER, AW

FRANCIS, PT

BOWEN, DM ^{[1
]}

机构：

[1] INST NEUROL,MARIAM MARKS DEPT NEUROCHEM,1 WAKEFIELD ST,LONDON WC1N 1PJ,ENGLAND

[2] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DEPT PSYCHIAT,LONDON,ENGLAND

来源：

BRAIN RESEARCH | 1991年 / 565卷 / 02期

关键词：

ALZHEIMERS DISEASE; D-CYCLOSERINE; N-METHYL-D-ASPARTATE RECEPTOR; GLYCINE RECEPTOR; HUMAN BRAIN;

D O I：

10.1016/0006-8993(91)91668-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The action of D-Cycloserine (DCS) at the strychnine-insensitive glycine recognition site of the NMDA receptor-ionophore complex has been studied with membranes from inferior parietal cortex of patients with Alzheimer's disease. The maximal response of the site, measured using [H-3]MK-801 binding, was 64% of that observed with glycine. Stimulation of binding induced by DCS in the presence of fixed concentrations of glycine resulted in a family of dose-response curves, consistent with the antibiotic having the property of a partial agonist at this glycine site. It is proposed that because of circumscribed glutamatergic pyramidal cell pathology DCS will have benefit for Alzheimer's patients over and above all other types of cognitive impairment.

引用

页码：345 / 348

页数：4

共 33 条

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