2.2 MB OF CONTIGUOUS NUCLEOTIDE-SEQUENCE FROM CHROMOSOME-III OF C-ELEGANS

被引：1280

作者：

WILSON, R

AINSCOUGH, R

ANDERSON, K

BAYNES, C

BERKS, M

BURTON, J

CONNELL, M

BONFIELD, J

COPSEY, T

COOPER, J

COULSON, A

CRAXTON, M

DEAR, S

DU, Z

DURBIN, R

FAVELLO, A

FRASER, A

FULTON, L

GARDNER, A

GREEN, P

HAWKINS, T

HILLIER, L

JIER, M

JOHNSTON, L

JONES, M

KERSHAW, J

KIRSTEN, J

LAISSTER, N

LATREILLE, P

LLOYD, C

MORTIMORE, B

OCALLAGHAN, M

PARSONS, J

PERCY, C

RIFKEN, L

ROOPRA, A

SAUNDERS, D

SHOWNKEEN, R

SIMS, M

SMALDON, N

SMITH, A

SMITH, M

SONNHAMMER, E

STADEN, R

SULSTON, J

THIERRYMIEG, J

THOMAS, K

VAUDIN, M

VAUGHAN, K

WATERSTON, R

机构：

[1] WASHINGTON UNIV,SCH MED,CTR GENOME SEQUENCING,ST LOUIS,MO 63110

[2] MRC,MOLEC BIOL LAB,CAMBRIDGE CB10 1RQ,CAMBS,ENGLAND

[3] SANGER CTR,CAMBRIDGE CB10 1RQ,CAMBS,ENGLAND

[4] CNRS,CTR RECH BIOCHIM MACROMOLEC & PHYS MATH,F-34033 MONTPELLIER,FRANCE

来源：

NATURE | 1994年 / 368卷 / 6466期

关键词：

D O I：

10.1038/368032a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

As part of our effort to sequence the 100-megabase (Mb) genome of the nematode Caenorhabditis elegans, we have completed the nucleotide sequence of a contiguous 2,181,032 base pairs in the central gene cluster of chromosome III. Analysis of the finished sequence has indicated an average density of about one gene per five kilobases; comparison with the public sequence databases reveals similarities to previously known genes for about one gene in three. In addition, the genomic sequence contains several intriguing features, including putative gene duplications and a variety of other repeats with potential evolutionary implications.

引用

页码：32 / 38

页数：7

共 49 条

[1]

Alschul S F, 1990, J Mol Biol, V215, P403

[2]

BANKIER AT, 1983, TECHNIQUES NUCLEIC B, V5, P1

[3]

BRENNER S, 1974, GENETICS, V77, P71

[4] NEMATODE HOMEOBOX CLUSTER [J].