CHEMOENZYMATIC SYNTHESIS OF ENANTIOMERICALLY PURE BETA,GAMMA-DISUBSTITUTED GAMMA-LACTONES

被引：6

作者：

THEIL, F

机构：

[1] Institut für Angewandte Chemie Berlin-Adlershof e.V., D-12484 Berlin

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00214-A

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of enantiomerically pure beta, gamma-disubstituted gamma-lactones is described based on the lipase-catalysed asymmetrisation of the cis-cyclopent-2-ene-1,4-diol derivatives 1 or 3. The cyclopentanones 7 and ent-7 have been obtained via epoxidation of the chiral monoacetates 2 or ent-2, respectively, followed by protecting group interconversion and oxidation. Baeyer-Villiger oxidation of 7 and ent-7 and subsequent acidic methanolysis furnished the title compounds 9 and ent-9, respectively.

引用

页码：1693 / 1698

页数：6

共 24 条

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