CHARACTERIZATION OF THE MACROMOLECULAR-SYNTHESIS (MMS) OPERON FROM LISTERIA-MONOCYTOGENES

被引:22
作者
METZGER, R
BROWN, DP
GREALISH, P
STAVER, MJ
VERSALOVIC, J
LUPSKI, JR
KATZ, L
机构
[1] ABBOTT LABS, ABBOTT PK, IL 60064 USA
[2] BAYLOR COLL MED, DEPT MOLEC & HUMAN GENET, HOUSTON, TX 77030 USA
[3] BAYLOR COLL MED, DEPT PEDIAT, HOUSTON, TX 77030 USA
关键词
DNA PRIMASE; DNAG; NUCLEOTIDE SEQUENCE; RPOD; SIGMA FACTOR;
D O I
10.1016/0378-1119(94)90649-1
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The macromolecular synthesis (MMS) operon consists of three genes: rpsU, which encodes the S21 ribosomal protein (in Bacillus subtilis (Bs), rpsU is replaced by orfP23 which encodes a protein of unknown function), dnaG, encoding the DNA primase involved in the initiation of chromosome replication, and rpoD, which encodes the principal sigma subunit of RNA polymerase. The operon was cloned in three segments from Listeria ia monocytogenes (Lm), initially using a probe designed from a highly conserved region of RpoD. Analysis of the nucleotide sequence revealed three genes: orfP17 (whose product, P17, is homologous to Bs P23), dnaG and rpoD. The Lm DnaG resembles the primase from Escherichia coli through the first two-thirds of the sequence. C-terminal similarity was observed between DnaG from Lm and Bs. Lm RpoD is similar to Bs SigA, shares identical DNA-binding domains with SigA, and is a member of the sigma(43) subgroup of the sigma(70) family.
引用
收藏
页码:161 / 166
页数:6
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