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CYCLIC ADP-RIBOSE, THE RYANODINE RECEPTOR AND CA2+ RELEASE

被引：136
作者：
SITSAPESAN, R
MCGARRY, SJ
WILLIAMS, AJ
机构：
[1] Cardiac Medicine, National Heart and Lung Institute, Imperial College, London, SW3 6LY, Dovehouse Street
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1995年 / 16卷 / 11期
关键词：
D O I：
10.1016/S0165-6147(00)89080-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In a variety of vertebrate and invertebrate tissues the ryanodine-sensitive Ca2+ channel is the pathway for Ca2+ release from intracellular stores. The mechanism for activation of the ryanodine receptor-channel complex appears to depend both on the ryanodine receptor isoform and the cell type. In addition, a complex combination of endogenous intracellular compounds regulates channel gating. In this article, Rebecca Sitsapesan, Stephen McGarry and Alan Williams review the mechanisms involved in cyclic ADP-ribose (cADPR)-induced Ca2+ release and discuss the likelihood that cADPR-activated Ca2+ release is mediated by one of the recognized isoforms of the ryanodine receptor-Ca2+ channel complex.
引用
收藏
页码：386 / 391
页数：6
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