CARDIOVASCULAR EFFECTS OF PLATELET-ACTIVATING-FACTOR

被引：8

作者：

HOLLAND, MR

MCINTYRE, TM

ZIMMERMAN, GA

PRESCOTT, SM

机构：

[1] UNIV UTAH,DEPT INTERNAL MED,SALT LAKE CITY,UT 84112

[2] UNIV UTAH,DEPT BIOCHEM,SALT LAKE CITY,UT 84112

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1991年 / 1卷 / 03期

关键词：

D O I：

10.1016/1050-1738(91)90005-Y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet-activating factor (PAF) is a unique biologically active phospholipid that is synthesized by many cells and tissues and has actions far more diverse than just platelet activation. PAF is probably a mediator of the normal inflammatory and thrombotic responses. Inappropriate or excessive production of PAF can lead to vascular injury, particularly via its proinflammatory effects, and marked hemodynamic derangements. There is evidence that PAF may play a role in clinical syndromes of shock, infarction, and reperfusion injury. Antagonists of the PAF receptor have been developed and have therapeutic potential in these common life-threatening disorders.

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页码：117 / 121

页数：5

相关论文

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