INTERMITTENT CORTICOSTEROID MAINTENANCE TREATMENT OF PSORIASIS - A DOUBLE-BLIND MULTICENTER TRIAL OF AUGMENTED BETAMETHASONE DIPROPIONATE OINTMENT IN A PULSE DOSE TREATMENT REGIMEN

被引:50
作者
KATZ, HI
PRAWER, SE
MEDANSKY, RS
KRUEGER, GG
MOONEY, JJ
JONES, ML
SAMSON, CR
机构
[1] SCHERING PLOUGH CORP,2000 GALLOPING HILL RD,KENILWORTH,NJ 07033
[2] MINNESOTA CLIN STUDY CTR,FRIDLEY,MN
[3] RESURRECT PROFESS BLDG,CHICAGO,IL
[4] UNIV UTAH,SALT LAKE CITY,UT 84112
来源
DERMATOLOGICA | 1991年 / 183卷 / 04期
关键词
BETAMETHASONE DIPROPIONATE; PSORIASIS; MAINTENANCE THERAPY;
D O I
10.1159/000247698
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Ninety psoriasis patients, who were either completely cleared of or manifested only a minimal presence of disease signs following 3-4 weeks of twice daily treatment with augmented betamethasone dipropionate (ABD) ointment 0.05%, were enrolled in this multicenter, double-blind, placebo-controlled study. The study was designed to determine if an intermittent pulse dose regimen of ABD ointment could safely and effectively maintain a remission disease status when treatment was applied in three consecutive applications 12 h apart, once a week for a maximum treatment period of 6 months. The disease of 60% of the patients in the active treatment group was successfully controlled for 6 months, while 80% of the placebo-treated patients experienced exacerbation of disease signs. No serious local or systemic treatment-related adverse experiences were reported. ABD ointment 0.05%, when applied using the intermittent treatment regimen described here, was shown to be a clinically beneficial and well-tolerated method of long-term (up to 6 months) maintenance therapy for psoriasis patients.
引用
收藏
页码:269 / 274
页数:6
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