THE ROLE OF INTESTINAL BACTERIA IN THE TRANSFORMATION OF SODIUM PICOSULFATE

被引：35

作者：

KIM, DH ^{[1
]}

HYUN, SH ^{[1
]}

SHIM, SB ^{[1
]}

KOBASHI, K ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM,SUGITANI,TOYAMA 93001,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 59卷 / 01期

关键词：

PICOSULFATE; BIOTRANSFORMATION; SULFOTRANSFERASE; INTESTINAL FLORA; LAXATIVE;

D O I：

10.1254/jjp.59.1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase). The biotransformation was activated by adding phenolic compounds such as phenol, acetaminophen and flavonoids. The enzyme activity related to this biotransformation was the highest in the contents of the caecum region of the intestine. The enzyme activity was 3.0-mu-mole/hr/g wet feces in humans and 0.75 in rats (pH 8.0). The optimal pH was 9.0.

引用

页码：1 / 5

页数：5

共 8 条

[1] HYDRAGOGUE AND LAXATIVE EFFECT OF SULFURIC-ACID ESTER AND FREE DIPHENOL OF 4,4'-DIHYDROXYDIPHENYL-(PYRIDYL-2)-METHANE [J].

FORTH, W ;

RUMMEL, W ;

ANDRES, H ;

NELL, G .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1972, 274 (01) :46-&

[2] PURIFICATION, CHARACTERIZATION AND REACTION-MECHANISM OF NOVEL ARYLSULFOTRANSFERASE OBTAINED FROM AN ANAEROBIC BACTERIUM OF HUMAN INTESTINE [J].

KIM, DH ;

KONISHI, L ;

KOBASHI, K .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 872 (1-2) :33-41

[3] THE ROLE OF INTESTINAL FLORA IN METABOLISM OF PHENOLIC SULFATE ESTERS [J].

KIM, DH ;

KOBASHI, K .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (20) :3507-3510

[4] A NOVEL TYPE OF ARYL SULFOTRANSFERASE OBTAINED FROM AN ANAEROBIC BACTERIUM OF HUMAN INTESTINE [J].

KOBASHI, K ;

FUKAYA, Y ;

KIM, DH ;

AKAO, T ;

TAKEBE, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 245 (02) :537-539

[5]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[6] UDP GLUCURONYLTRANSFERASE AND PHENOLSULFOTRANSFERASE INVIVO AND INVITRO - CONJUGATION OF HARMOL AND HARMALOL [J].

MULDER, GJ ;

HAGEDOORN, AH .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (15) :2101-2109

[7] LIVER AS MAJOR ORGAN OF PHENOL DETOXICATION [J].

POWELL, GM ;

MILLER, JJ ;

OLAVESEN, AH ;

CURTIS, CG .

NATURE, 1974, 252 (5480) :234-235

[8]

SCHELINE RR, 1973, PHARMACOL REV, V25, P451

← 1 →