NICOTINE STIMULATES MATURATIONAL GONADOTROPIN (GTH2) RELEASE FROM CARP (CYPRINUS-CARPIO L) PITUITARY-CELLS

被引：4

作者：

MIKOLAJCZYK, T ^{[1
]}

WEIL, C ^{[1
]}

BRETON, B ^{[1
]}

机构：

[1] AGR ACAD KRAKOW MYDLNIKI, DEPT ICHTHYOBIOL & FISHERIES, PL-30149 KRAKOW, POLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1993年 / 105卷 / 01期

关键词：

D O I：

10.1016/0742-8413(93)90062-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Perifusion of dispersed pituitary cells and pituitary cell culture was used to investigate the effects of cholinergic drugs on the secretion of maturational gonadotropin (GtH2) in carp. 2. Nicotine strongly, and in a dose dependent manner, stimulated GtH2 release in male and in female carp (from 10(-8) M in the perifusion and 10(-10) M in the cells cultures). 3. Nicotine is 10 times more active in females than in males. 4. The results suggest that in carp, nicotine stimulates GtH2 release directly from the pituitary cells, indicating a possible involvement of a cholinergic system in the regulation of GtH2 secretion in teleost fish.

引用

页码：83 / 88

页数：6

共 29 条

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