ACUTE ADMINISTRATION OF ANGIOTENSIN-II IMPROVES LONG-TERM HABITUATION IN THE CRAB CHASMAGNATHUS

被引:19
作者
DELORENZI, A [1 ]
PEDREIRA, ME [1 ]
ROMANO, A [1 ]
PIROLA, CJ [1 ]
NAHMOD, VE [1 ]
MALDONADO, H [1 ]
机构
[1] UNIV BUENOS AIRES, FAC CIENCIAS EXACTAS & NAT, DEPT BIOL, FISIOL COMPORTAMIENTO ANIM LAB, RA-1428 BUENOS AIRES, DF, ARGENTINA
关键词
ANGIOTENSIN II; LEARNING; MEMORY; CHASMAGNATHUS; CRAB; SARALASIN; RECEPTORS; INVERTEBRATES;
D O I
10.1016/0304-3940(95)11876-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A shadow moving overhead acts as a danger stimulus and elicits an escape response in the crab Chasmagnathus granulatus that habituates after 15 trials and for a long period. A shorter training of ten trials fails to induce long-term habituation; however, a good retention of the habituated response is manifest after a 24-h interval when angiotensin II (AII) (10(-6) M, 3 ng/g) is injected post-training. By contrast, no amnestic effect of AII was found even though high doses were administered. The facilitatory effect of AII is suppressed by saralasin (10(-7) M, 0.3 ng/g), a specific angiotensin II receptor antagonist. Results are considered as suggesting that angiotensin on memory processes might have emerged early in evolution.
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页码:193 / 196
页数:4
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