EFFECTS OF DNA METHYLATION ON DNA-BINDING PROTEINS AND GENE-EXPRESSION

被引：603

作者：

TATE, PH ^{[1
]}

BIRD, AP ^{[1
]}

机构：

[1] UNIV EDINBURGH, EDINBURGH EH8 9YL, MIDLOTHIAN, SCOTLAND

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/0959-437X(93)90027-M

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA methyltransferase is needed for normal development, perhaps because DNA methylation plays a part in the control of gene activity. It is clear that the methylation of promoters often leads to repression of transcription. Studies of the mechanism suggest that repression may either result from the direct effects of methylation on transcription factors, or may be indirectly caused by repressor proteins that bind to methylated DNA. Current evidence suggests that both mechanisms can be involved.

引用

页码：226 / 231

页数：6

共 55 条

[1] 5-METHYLCYTOSINE IS LOCALIZED IN NUCLEOSOMES THAT CONTAIN HISTONE H-1
BALL, DJ
GROSS, DS
GARRARD, WT
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (18): : 5490 - 5494
[2] BEDNARIK DP, 1991, NEW BIOL, V3, P969
[3] CYTOSINE METHYLATION IN CTF AND SP1 RECOGNITION SITES OF AN HSV TK PROMOTER - EFFECTS ON TRANSCRIPTION INVIVO AND ON FACTOR BINDING INVITRO
BENHATTAR, J
BEARD, P
JIRICNY, J
[J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (24) : 10179 - 10190
[4] THE ESSENTIALS OF DNA METHYLATION
BIRD, A
[J]. CELL, 1992, 70 (01) : 5 - 8
[5] DNA METHYLATION INHIBITS TRANSCRIPTION INDIRECTLY VIA A METHYL-CPG BINDING-PROTEIN
BOYES, J
BIRD, A
[J]. CELL, 1991, 64 (06) : 1123 - 1134
[6] REPRESSION OF GENES BY DNA METHYLATION DEPENDS ON CPG DENSITY AND PROMOTER STRENGTH - EVIDENCE FOR INVOLVEMENT OF A METHYL-CPG BINDING-PROTEIN
BOYES, J
BIRD, A
[J]. EMBO JOURNAL, 1992, 11 (01) : 327 - 333
[7] DNA METHYLATION AND GENE ACTIVITY
CEDAR, H
[J]. CELL, 1988, 53 (01) : 3 - 4
[8] CHOI YC, 1991, J BIOL CHEM, V266, P20504
[9] CPG METHYLATION INHIBITS PROENKEPHALIN GENE-EXPRESSION AND BINDING OF THE TRANSCRIPTION FACTOR AP-2
COMB, M
GOODMAN, HM
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (13) : 3975 - 3982
[10] HIGHLY REPEATED SITES IN THE APOLIPOPROTEIN(A) GENE RECOGNIZED BY METHYLATED DNA-BINDING PROTEIN, A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN
EHRLICH, KC
EHRLICH, M
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (09) : 4957 - 4960

← 1 2 3 4 5 6 →