MUTATIONAL ACTIVATION OF THE K-RAS ONCOGENE - A POSSIBLE PATHOGENETIC FACTOR IN ADENOCARCINOMA OF THE LUNG

被引:528
作者
RODENHUIS, S
VANDEWETERING, ML
MOOI, WJ
EVERS, SG
VANZANDWIJK, N
BOS, JL
机构
[1] NETHERLANDS CANC INST,DIV EXPTL THERAPY,1066 CX AMSTERDAM,NETHERLANDS
[2] NETHERLANDS CANC INST,DIV CLIN ONCOL,1066 CX AMSTERDAM,NETHERLANDS
[3] STATE UNIV LEIDEN,SYLVIUS LABS,DEPT MED BIOCHEM,2312 AV LEIDEN,NETHERLANDS
关键词
D O I
10.1056/NEJM198710083171504
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:929 / 935
页数:7
相关论文
共 37 条
  • [1] HISTOLOGIC TYPE OF LUNG-CANCER IN RELATION TO SMOKING-HABITS, YEAR OF DIAGNOSIS AND SITES OF METASTASES
    AUERBACH, O
    GARFINKEL, L
    PARKS, VR
    [J]. CHEST, 1975, 67 (04) : 382 - 387
  • [2] Barbacid M, 1986, Important Adv Oncol, P3
  • [3] MUTAGENS, ONCOGENES AND CANCER
    BARBACID, M
    [J]. TRENDS IN GENETICS, 1986, 2 (07) : 188 - 192
  • [4] BOS JL, 1987, BLOOD, V69, P1237
  • [5] AMINO-ACID SUBSTITUTIONS AT CODON-13 OF THE N-RAS ONCOGENE IN HUMAN ACUTE MYELOID-LEUKEMIA
    BOS, JL
    TOKSOZ, D
    MARSHALL, CJ
    VERLAANDEVRIES, M
    VEENEMAN, GH
    VANDEREB, AJ
    VANBOOM, JH
    JANSSEN, JWG
    STEENVOORDEN, ACM
    [J]. NATURE, 1985, 315 (6022) : 726 - 730
  • [6] PREVALENCE OF RAS GENE-MUTATIONS IN HUMAN COLORECTAL CANCERS
    BOS, JL
    FEARON, ER
    HAMILTON, SR
    VERLAANDEVRIES, M
    VANBOOM, JH
    VANDEREB, AJ
    VOGELSTEIN, B
    [J]. NATURE, 1987, 327 (6120) : 293 - 297
  • [7] A HUMAN GASTRIC-CARCINOMA CONTAINS A SINGLE MUTATED AND AN AMPLIFIED NORMAL ALLELE OF THE KI-RAS ONCOGENE
    BOS, JL
    VERLAANDEVRIES, M
    MARSHALL, CJ
    VEENEMAN, GH
    VANBOOM, JH
    VANDEREB, AJ
    [J]. NUCLEIC ACIDS RESEARCH, 1986, 14 (03) : 1209 - 1217
  • [8] 3 DIFFERENT MUTATIONS IN CODON-61 OF THE HUMAN N-RAS GENE DETECTED BY SYNTHETIC OLIGONUCLEOTIDE HYBRIDIZATION
    BOS, JL
    VERLAANDEVRIES, M
    JANSEN, AM
    VEENEMAN, GH
    VANBOOM, JH
    VANDEREB, AJ
    [J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (23) : 9155 - 9163
  • [9] ASSAY FOR NANOGRAM QUANTITIES OF DNA IN CELLULAR HOMOGENATES
    BRUNK, CF
    JONES, KC
    JAMES, TW
    [J]. ANALYTICAL BIOCHEMISTRY, 1979, 92 (02) : 497 - 500
  • [10] RESISTANCE TO METHOTREXATE DUE TO GENE AMPLIFICATION IN A PATIENT WITH ACUTE-LEUKEMIA
    CARMAN, MD
    SCHORNAGEL, JH
    RIVEST, RS
    SRIMATKANDADA, S
    PORTLOCK, CS
    DUFFY, T
    BERTINO, JR
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1984, 2 (01) : 16 - 20