PLASMODIUM-BERGHEI - THE ANTIMALARIAL ACTION OF ARTEMISININ AND SODIUM ARTELINATE INVIVO AND INVITRO, STUDIED BY FLOW-CYTOMETRY

被引:40
作者
VANVIANEN, PH
KLAYMAN, DL
LIN, AJ
LUGT, CB
VANENGEN, AL
VANDERKAAY, HJ
MONS, B
机构
[1] ACF CHEM BV,3600 AC MAARSSEN,NETHERLANDS
[2] WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307
关键词
Antimalarial action; Artemisia annua; cultures; Flow cytometry; Hoechst-33258; Plasmodium berghei; Synchronous infections;
D O I
10.1016/0014-4894(90)90092-Q
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Sodium artelinate, a new water-soluble and relatively stable derivative of artemisinin, and its parent compound were tested for their antimalarial action. Experiments were done vitro with synchronous cultures of Plasmodium berghei. The inhibition of growth by different concentrations of sodium artelinate and artemisinin was determined using flow cytometry. In vivo testing was done by subcutaneous injection of each drug in mice infected with P. berghei. Sodium artelinate, being stable in aqueous solution, was also administered orally to infected mice by its addition to their drinking water. Comparison of the parent compound and the derivative showed that sodium artelinate was slightly less active than artemisinin both in culture and in vivo. However, after oral administration of sodium artelinate, parasites were cleared from the blood with one-half to one-tenth of the dose used in the experiments with subcutaneous injection. The number of mice which were cured by oral administration of sodium artelinate was greater than after subcutaneous injection, even with a total oral dose lower than the injected dose. © 1990.
引用
收藏
页码:115 / 123
页数:9
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