A RANDOMIZED STUDY TO COMPARE ORAL FLUCONAZOLE TO AMPHOTERICIN-B IN THE PREVENTION OF FUNGAL-INFECTIONS IN PATIENTS WITH ACUTE-LEUKEMIA

被引:68
作者
ROZENBERGARSKA, M
DEKKER, AW
BRANGER, J
VERHOEF, J
机构
[1] STATE UNIV UTRECHT HOSP, DEPT CLIN MICROBIOL, 3511 GV UTRECHT, NETHERLANDS
[2] STATE UNIV UTRECHT HOSP, DEPT CLIN HAEMATOL, 3511 GV UTRECHT, NETHERLANDS
[3] STATE UNIV UTRECHT HOSP, INFECT DIS LAB, 3511 GV UTRECHT, NETHERLANDS
关键词
D O I
10.1093/jac/27.3.369
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In a prospective randomized study the efficacy of fluconazole (50 mg in one single daily dose) was compared with oral amphotericin B in suspension and tablets (each 200 mg four times daily) for prevention of colonization and subsequent infection by yeasts in 50 patients undergoing remission induction treatment for acute leukaemia. All patients received ciprofloxacin for prevention of bacterial infections. Fluconazole was as effective as amphotericin B in preventing severe local and disseminated fungal disease (one documented and one highly suspected infection in each group of patients). Fluconazole effectively prevented yeast colonization of the oropharynx but was less effective than amphotericin B in preventing colonization of the lower alimentary tract. Fifty-two percent of patients receiving fluconazole had persistent positive stool cultures as compared to 4% in the amphotericin B group (P < 0.01).Fluconazole was better tolerated than amphotericin B. One patient developed an extended rash leading to the termination of fluconazole. © 1991 The British Society for Antimicrobial Chemotherapy.
引用
收藏
页码:369 / 376
页数:8
相关论文
共 30 条
  • [1] EFFECT OF SYSTEMIC ANTIMICROBIAL PROPHYLAXIS ON MICROBIAL-FLORA
    BODEY, GP
    ROSENBAUM, B
    VALDIVIESO, M
    BOLIVAR, R
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 21 (03) : 367 - 372
  • [2] FUNGAL INFECTIONS COMPLICATING ACUTE LEUKEMIA
    BODEY, GP
    [J]. JOURNAL OF CHRONIC DISEASES, 1966, 19 (06): : 667 - +
  • [3] DEGREGORIO MW, 1982, CANCER, V50, P2780, DOI 10.1002/1097-0142(19821215)50:12&lt
  • [4] 2780::AID-CNCR2820501215&gt
  • [5] 3.0.CO
  • [6] 2-P
  • [7] PREVENTION OF INFECTION BY TRIMETHOPRIM-SULFAMETHOXAZOLE PLUS AMPHOTERICIN-B IN PATIENTS WITH ACUTE NONLYMPHOCYTIC LEUKEMIA
    DEKKER, AW
    ROZENBERGARSKA, M
    SIXMA, JJ
    VERHOEF, J
    [J]. ANNALS OF INTERNAL MEDICINE, 1981, 95 (05) : 555 - 559
  • [8] Evans E. G. V., 1979, Recent Advances in Infection, P55
  • [9] ORAL AMPHOTERICIN FOR CANDIDIASIS IN PATIENTS WITH HEMATOLOGIC NEOPLASMS - AUTOPSY STUDY
    EZDINLI, EZ
    OSULLIVAN, DD
    WASSER, LP
    KIM, U
    STUTZMAN, L
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1979, 242 (03): : 258 - 260
  • [10] FLUCONAZOLE, A NEW ANTIFUNGAL AGENT
    GALGIANI, JN
    [J]. ANNALS OF INTERNAL MEDICINE, 1990, 113 (03) : 177 - 179