HTLV-1 IN ACQUIRED ADULT MYOPATHY

被引：12

作者：

DICKOFF, DJ

SIMPSON, DM

WILEY, CA

MENDELSON, SG

FARRAYE, J

WOLFE, DE

WACHSMAN, W

机构：

[1] MT SINAI MED CTR,DEPT NEUROL,NEW YORK,NY 10029

[2] UNIV CALIF SAN DIEGO,DEPT PATHOL,LA JOLLA,CA 92093

来源：

MUSCLE & NERVE | 1993年 / 16卷 / 02期

关键词：

MYOPATHY; HTLV-1; IMMUNOHISTOCHEMISTRY; PCR;

D O I：

10.1002/mus.880160207

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a 53-year-old Jamaican man with 20 years of progressing weakness involving proximal limb muscles and neck flexors. Serum CK was 1100 IU/L. EMG demonstrated spontaneous activity, myopathic motor units, and full recruitment patterns in weak muscles. Muscle biopsy revealed marked myofiber degeneration with extensive fibrosis, suggesting a chronic myopathic process. HTLV-1 antibody was present in serum in high titers by ELISA and Western blot. Immunohistochemistry with rabbit polyclonal antisera to HTLV-1 showed rare staining myocytes. PCR demonstrated HTLV-1 DNA in frozen muscle tissue. This myopathy, associated with HTLV-1 infection, has clinical and pathological features similar to a dystrophy. We recommend serological screening for HTLV-1 in cryptogenic adult myopathies.

引用

页码：162 / 165

页数：4

共 12 条

[1] HTLV-I ASSOCIATED MYELOPATHY - CLINICOPATHOLOGICAL CORRELATION WITH LOCALIZATION OF PROVIRUS TO SPINAL-CORD [J].