HISTAMINE AS AN AUTOCRINE GROWTH-FACTOR IN EXPERIMENTAL MAMMARY CARCINOMAS

被引：51

作者：

CRICCO, GP ^{[1
]}

DAVIO, CA ^{[1
]}

MARTIN, G ^{[1
]}

ENGEL, N ^{[1
]}

FITZSIMONS, CP ^{[1
]}

BERGOC, RM ^{[1
]}

RIVERA, ES ^{[1
]}

机构：

[1] UNIV BUENOS AIRES,FAC FARM & BIOQUIM,RADIOISOTOPES LAB,RA-1113 BUENOS AIRES,DF,ARGENTINA

来源：

AGENTS AND ACTIONS | 1994年 / 43卷 / 1-2期

关键词：

HISTAMINE RECEPTORS; HISTAMINE; HISTIDINE DECARBOXYLASE; GROWTH FACTORS; TUMOR GROWTH;

D O I：

10.1007/BF02005757

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to determine the role of endogenous histamine in the regulation of cell growth, the in vitro action of fluoromethyl-histidine (MFMH) was studied in experimental mammary carcinomas induced in rats. Tumor cells were cultured in soft agar using the clonogenic agar technique. The MFMH was added in different concentrations (0.01-100 mu M). The effect observed was a 60% inhibition on colony formation with a maximal effect at concentrations over 10 mu M. This action was completely reverted by the H2 agonists dimaprit and arpromidine with an IC50 value of 1 mu M. The action of the H2 agonists when added alone was a significant increase in cell proliferation (135%), while the H1 agonist produced a dose-dependent inhibition on cell growth. In these experimental carcinomas endogenous histamine is critical for cell proliferation and one of its major effects may be the stimulation of cell growth by acting on specific H2 membrane receptors.

引用

页码：17 / 20

页数：4

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