HYALURONIC-ACID MODULATES ACUTE AND CHRONIC INFLAMMATION

被引：77

作者：

IALENTI, A

DIROSA, M

机构：

[1] Department of Experimental Pharmacology, University of Naples 'Federico II', Naples, I-80131, Via Domenico Montesano

来源：

AGENTS AND ACTIONS | 1994年 / 43卷 / 1-2期

关键词：

ADJUVANT ARTHRITIS; CARRAGEENAN EDEMA; HYALURONIC ACID;

D O I：

10.1007/BF02005763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have studied the effect of hyaluronic acid (HA) in two standard models of acute and chronic inflammation in the rat, i.e. carrageenin oedema and adjuvant arthritis. Our results show that HA was able to inhibit, in a dose-related fashion, both types of inflammatory reactions. These findings suggest that HA may have a modulatory role in the inflammatory process and may explain, at least in part, the protective role of HA in the inflammatory cartilage damage.

引用

页码：44 / 47

页数：4

共 18 条

[1]

BRANDT K, 1970, ARTHRITIS RHEUM, V13, P308

[2] AUTOIMMUNITY TO CHAPERONINS IN THE PATHOGENESIS OF ARTHRITIS AND DIABETES [J].

COHEN, IR .

ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 :567-589

[3] EFFECT OF CONNECTIVE TISSUE INTERCELLULAR MATRIX ON LYMPHOCYTE STIMULATION .1. SUPPRESSION OF LYMPHOCYTE STIMULATION BY HYALURONIC ACID [J].

DARZYNKIEWICZ, Z ;

BALAZS, EA .

EXPERIMENTAL CELL RESEARCH, 1971, 66 (01) :113-+

[4] STUDIES OF MEDIATORS OF ACUTE INFLAMMATORY RESPONSE INDUCED IN RATS IN DIFFERENT SITES BY CARRAGEENAN AND TURPENTINE [J].

DIROSA, M ;

GIROUD, JP ;

WILLOUGHBY, DA .

JOURNAL OF PATHOLOGY, 1971, 104 (01) :15-+

[5] CIRCULATING HYALURONATE IN RHEUMATOID-ARTHRITIS - RELATIONSHIP TO INFLAMMATORY ACTIVITY AND THE EFFECT OF CORTICOSTEROID-THERAPY [J].

ENGSTROMLAURENT, A ;

HALLGREN, R .

ANNALS OF THE RHEUMATIC DISEASES, 1985, 44 (02) :83-88

[6]

FORRESTER JV, 1981, J CELL SCI, V50, P329

[7]

FORRESTER JV, 1981, J CELL SCI, V48, P315

[8] UPTAKE AND DEGRADATION OF HYALURONAN IN LYMPHATIC TISSUE [J].

FRASER, JRE ;

KIMPTON, WG ;

LAURENT, TC ;

CAHILL, RNP ;

VAKAKIS, N .

BIOCHEMICAL JOURNAL, 1988, 256 (01) :153-158

[9] HYALURONATE INHIBITION OF CELL-PROLIFERATION [J].

GOLDBERG, RL ;

TOOLE, BP .

ARTHRITIS AND RHEUMATISM, 1987, 30 (07) :769-778

[10]

HAYNES BF, 1991, CANCER CELL-MON REV, V3, P347

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