DEVELOPMENT OF PACKED CAPILLARY COLUMN ELECTROCHROMATOGRAPHY MASS-SPECTROMETRY

被引：59

作者：

GORDON, DB

LORD, GA

JONES, DS

机构：

[1] UNIV MANCHESTER,INST SCI & TECHNOL,MICHAEL BARBER CTR MASS SPECTROMETRY,MANCHESTER M60 1QD,LANCS,ENGLAND

[2] KRATOS ANALYT LTD,MANCHESTER M31 2LD,ENGLAND

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1994年 / 8卷 / 07期

关键词：

D O I：

10.1002/rcm.1290080711

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enhanced performance of electro-osmotically driven high performance liquid chromatography (HPLC) using reversed-phase packed capillaries has been evaluated for coupling to mass spectrometers, as an alternative to both conventional pressure-driven elution, and to micellar electrokinetic capillary chromatography for the separation of neutral analytes. An off-line comparison of electro-osmotically driven versus pressure driven chromatography for the separation of an aromatic mixture shows the superiority of the method over conventional HPLC. Coupling of the technique with continuous-flow fast-atom bombardment for the analysis of a steroid mixture is described.

引用

页码：544 / 548

页数：5

共 12 条

[1]

GORDON DB, 1993, 41ST P ANN C MASS SP, pA57

[2]

GORDON DB, 1992, 19TH BRIT MASS SPECT

[3] PSEUDO-ELECTROCHROMATOGRAPHY NEGATIVE-ION ELECTROSPRAY MASS-SPECTROMETRY OF AROMATIC GLUCURONIDES AND FOOD COLORS [J].