MONKEY ANTIGEN CROSSREACTING WITH CARCINOEMBRYONIC ANTIGEN, CEA

被引：16

作者：

ENGVALL, E

VUENTO, M

RUOSLAHTI, E

机构：

[1] CITY HOPE NATL MED CTR, DEPT IMMUNOL, DUARTE, CA 91010 USA

[2] UNIV HELSINKI, DEPT SEROL & BACTERIOL, SF-00290 HELSINKI, FINLAND

来源：

BRITISH JOURNAL OF CANCER | 1976年 / 34卷 / 04期

关键词：

D O I：

10.1038/bjc.1976.176

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Normal monkey [Macaca iris] tissues were found to contain an antigen which crossreacts immunologically with the CEA of the human digestive tract [prepared from a colon carcinoma]. The monkey antigen reacted with complete or partial identity to the normal crossreacting antigen (NCA) in humans when tested in immunodiffusion against anti-CEA or anti-NCA. Extracts of monkey tissues were inhibitory in radioimmunoassays measuring human NCA. It is possible that monkey fetuses and colonic tumors contain CEA. [This monkey may be useful as an animal model in studies of CEA.].

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页码：341 / 345

页数：5

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