STUDIES ON WF-3681, A NOVEL ALDOSE REDUCTASE INHIBITOR .4. EFFECT OF FR-62765, A DERIVATIVE OF WF-3681, ON THE DIABETIC NEUROPATHY IN RATS

被引:4
作者
NISHIKAWA, M
YOSHIDA, K
OKAMOTO, M
ITOH, Y
KOHSAKA, M
机构
[1] Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki 300-26, 5-2-3 Tokodai, Tsukuba
关键词
D O I
10.7164/antibiotics.44.441
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Pharmacokinetic properties of WF-3681 and FR-62765 in rats were examined. FR-62765 showed higher peak concentrations in the plasma and higher concentrations in the sciatic nerve than WF-3681 when each compound was administered orally to rats. We therefore evaluated FR-62765 in rats with diabetic neuropathy. As a result, FR-62765 at 32 mg/kg/day administered for 3 weeks to streptozotocin-induced diabetic rats significantly prevented the accumulation of sorbitol in the sciatic nerve and the reduction of motor nerve conduction velocity in the tail. From these results it was concluded that the aldose reductase inhibitor FR-62765 might be a useful drug for diabetic neuropathy.
引用
收藏
页码:441 / 444
页数:4
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