SPONTANEOUS NUCLEATION OF MICROTUBULES

被引：55

作者：

FYGENSON, DK

FLYVBJERG, H

SNEPPEN, K

LIBCHABER, A

LEIBLER, S

机构：

[1] PRINCETON UNIV,DEPT BIOL,PRINCETON,NJ 08544

[2] PRINCETON UNIV,DEPT PHYS,PRINCETON,NJ 08544

[3] ISAAC NEWTON INST MATH SCI,CAMBRIDGE CB4 0EH,ENGLAND

[4] NIELS BOHR INST,CONNECT,DK-2100 COPENHAGEN O,DENMARK

来源：

PHYSICAL REVIEW E | 1995年 / 51卷 / 05期

关键词：

D O I：

10.1103/PhysRevE.51.5058

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

The spontaneous nucleation of individual microtubules from tubulin dimers is observed directly under conditions of marginal nucleation. The results are compared with measurements of bulk turbidity following a deep quench [W. A. Voter and H. P. Erickson, J. Biol. Chem. 259, 10 430 (1984)]. The size of the critical microtubule nucleus is 12±2 tubulin dimers in the two regimes, but the assembly pathway is different. © 1995 The American Physical Society.

引用

页码：5058 / 5063

页数：6

共 14 条

[1]

BAYLEY PM, 1990, J CELL SCI, V95, P329

[2]

BERNE BJ, 1974, J MOL BIOL, V89, P737

[3] KINETIC-ANALYSIS OF COOPERATIVITY IN TUBULIN POLYMERIZATION IN PRESENCE OF GUANOSINE DIPHOSPHATE OR TRIPHOSPHATE NUCLEOTIDES [J].