PHENYLARSINE OXIDE STIMULATES PYRIDINE NUCLEOTIDE-LINKED CA2+ RELEASE FROM RAT-LIVER MITOCHONDRIA

被引：23

作者：

SCHWEIZER, M ^{[1
]}

DURRER, P ^{[1
]}

RICHTER, C ^{[1
]}

机构：

[1] ETH ZURICH,SWISS FED INST TECHNOL,BIOCHEM LAB 1,CH-8092 ZURICH,SWITZERLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1994年 / 48卷 / 05期

关键词：

CALCIUM RELEASE; INTACTNESS; MEMBRANE POTENTIAL; PYRIDINE NUCLEOTIDES; SULFHYDRYLS;

D O I：

10.1016/0006-2952(94)90367-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rat liver mitochondria contain a specific Ca2+ release pathway which operates when oxidized mitochondrial pyridine nucleotides are hydrolysed to ADPribose and nicotinamide. Here we report that the hydrophobic bifunctional thiol reagent phenylarsine oxide (PhAsO) at low concentrations stimulates this pathway by promoting a Ca2+-dependent hydrolysis of oxidized mitochondrial pyridine nucleotides. Ca2+ release is inhibited by cyclosporine A or m-iodobenzylguanidine, compounds known to prevent intramitochondrial pyridine nucleotide hydrolysis or protein mono(ADPribosyl)ation, respectively. At higher concentrations, PhAsO causes non-specific leakiness of mitochondria.

引用

页码：967 / 973

页数：7

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