Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation

被引:77
作者
Walls, EK
Phillips, RJ
Wang, FB
Holst, MC
Powley, TL
机构
关键词
celiac vagotomy; duodenum; food intake; nutrient infusions; vagus nerve; visceral afferents;
D O I
10.1152/ajpregu.1995.269.6.R1410
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The arrival of nutrients in the gastrointestinal tract suppresses intake. To specify the neural pathways and receptor locations of this feedback, we examined the effects of intraduodenal infusions of 10 nutrients plus saline on short-term food intake of rats with selective deafferentations of vagal celiac branches. Three response profiles were observed: 1) isotonic saline, 5.6% glycerol, and 3% fructose did not inhibit intake of controls or selectively deafferented animals; 2) 3% glucose, 3% maltose, 3% L-phenylalanine, 12% Isocal, and 1.4% oleic acid suppressed intake of controls, but this inhibition was eliminated by vagal celiac deafferentation; and 3) 3% casein hydrolysate and 24% Isocal suppressed intake of controls and rats with selective vagotomies, although the latter exhibited significantly less suppression. In addition, elimination of celiac afferents chronically reduced meal size (i.e., first 30-min intake) without reducing daily food intake or body weight. Furthermore, D-phenylalanine infusions produced a delayed suppression of food intake in controls (possibly from intraluminal irritation); however, this reduction was eliminated with celiac deafferentation. Overall, this experiment indicates that vagal celiac afferents are critical for preabsorptive detection of some energy-yielding molecules or properties of nutrient solutions (as well as, perhaps, intraluminal inflammation), but not others, which are still detected, although only partially.
引用
收藏
页码:R1410 / R1419
页数:10
相关论文
共 32 条
[1]  
Barnes CD, 1992, NEUROANATOMY PHYSL A, P221
[2]   TOPOGRAPHY OF EFFERENT VAGAL INNERVATION OF THE RAT GASTROINTESTINAL-TRACT [J].
BERTHOUD, HR ;
CARLSON, NR ;
POWLEY, TL .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (01) :R200-R207
[3]   COMPARISON OF GASTRIC, DUODENAL AND JEJUNAL CONTRIBUTIONS TO THE INHIBITION OF FOOD-INTAKE IN THE RAT [J].
CANBEYLI, RS ;
KOOPMANS, HS .
PHYSIOLOGY & BEHAVIOR, 1984, 33 (06) :951-957
[4]   MUCOSAL RECEPTORS IN GASTRIC ANTRUM AND SMALL-INTESTINE OF RAT WITH AFFERENT-FIBERS IN CERVICAL VAGUS [J].
CLARKE, GD ;
DAVISON, JS .
JOURNAL OF PHYSIOLOGY-LONDON, 1978, 284 (NOV) :55-67
[5]   CONDITIONED TASTE-AVERSIONS - VAGAL AND CIRCULATORY MEDIATION OF THE TOXIC UNCONDITIONED STIMULUS [J].
COIL, JD ;
ROGERS, RC ;
GARCIA, J ;
NOVIN, D .
BEHAVIORAL BIOLOGY, 1978, 24 (04) :509-519
[6]   LONGITUDINAL COLUMNAR ORGANIZATION WITHIN THE DORSAL MOTOR NUCLEUS REPRESENTS SEPARATE BRANCHES OF THE ABDOMINAL VAGUS [J].
FOX, EA ;
POWLEY, TL .
BRAIN RESEARCH, 1985, 341 (02) :269-282
[7]   THE INFLUENCE OF GASTROINTESTINAL INFUSION OF FATS ON REGULATION OF FOOD-INTAKE IN PIGS [J].
GREGORY, PC ;
RAYNER, DV .
JOURNAL OF PHYSIOLOGY-LONDON, 1987, 385 :471-481
[8]   DYNAMICS OF GASTRIC-EMPTYING DURING AND AFTER STOMACH FILL [J].
KAPLAN, JM ;
SPECTOR, AC ;
GRILL, HJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (04) :R813-R819
[9]  
KRALY FS, 1986, APPETITE, V7, P1, DOI 10.1016/S0195-6663(86)80038-1
[10]   EFFECT OF CALORIC CONTENT AND COMPOSITION OF A LIQUID MEAL ON GASTRIC-EMPTYING IN THE RAT [J].
MAERZ, LL ;
SANKARAN, H ;
SCHARPF, SJ ;
DEVENEY, CW .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1994, 267 (05) :R1163-R1167