NO ASSOCIATION OF APC RESISTANCE WITH MYOCARDIAL-INFARCTION

被引：37

作者：

BIASIUTTI, FD ^{[1
]}

MERLO, C ^{[1
]}

FURLAN, M ^{[1
]}

SULZER, I ^{[1
]}

BINDER, BR ^{[1
]}

LAMMLE, B ^{[1
]}

机构：

[1] UNIV VIENNA,DEPT MED PHYSIOL,CLIN EXPTL PHYSIOL LAB,A-1090 VIENNA,AUSTRIA

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 1995年 / 6卷 / 05期

关键词：

APC RESISTANCE; MYOCARDIAL INFARCTION; THROMBOSIS;

D O I：

10.1097/00001721-199507000-00013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Resistance to activated protein C (APC resistance) due to the factor V mutation 506 Arg-->Gln (factor V Leiden) is the most prevalent inherited risk factor for venous thromboembolism. Its association with arterial thromboembolic disease, however, is still controversial. In the present study we found no difference between the prevalence of APC resistance (assessed by the ratio of the aPTT with and without added APC) in 134 non-anticoagulated survivors of myocardial infarction and that in 100 controls of similar age and sex distribution (2.2% and 2.0%, respectively). Patients showed a significantly higher median value for the aPTT ratio than controls (2.85 and 2.66, respectively), a fact we could not explain by our data.

引用

页码：456 / 459

页数：4

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