DEXAMETHASONE ATTENUATES EXERCISE-INDUCED DENTAL ANALGESIA IN MAN

被引：65

作者：

KEMPPAINEN, P ^{[1
]}

PAALASMAA, P ^{[1
]}

PERTOVAARA, A ^{[1
]}

ALILA, A ^{[1
]}

JOHANSSON, G ^{[1
]}

机构：

[1] UNIV HELSINKI,DEPT PHYSIOL,SILTAVUORENPENGER 20J,SF-00170 HELSINKI 17,FINLAND

来源：

BRAIN RESEARCH | 1990年 / 519卷 / 1-2期

关键词：

Adrenocorticotropin; Analgesia; Dexamethasone; Exercise; Stress; Tooth pulp;

D O I：

10.1016/0006-8993(90)90096-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of dexamethasone on exercise-induced adrenocorticotropin (ACTH) secretion and dental analgesia was studied in healthy human subjects. Different levels of exercise (100-200 W) were produced by a cycle ergometer. Dental pain thresholds were tested with a constant current stimulator. Dental pain thresholds were elevated with increasing work loads, and the elevation was still significant 30 min after the end of the exercise. Dexamethasone produced a significant reversal of exercise-induced pain threshold elevations concomitantly with the suppression of exercise-induced ACTH release. The results suggest that the corticotropin releasing factor-ACTH axis is involved in the exercise-induced analgesia. © 1990.

引用

页码：329 / 332

页数：4

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