THE ACE INHIBITOR [H-3] SQ29,852 IDENTIFIES A HIGH-AFFINITY RECOGNITION SITE LOCATED IN THE HUMAN TEMPORAL CORTEX

被引：7

作者：

BARNES, NM

COSTALL, B

EGLI, P

HOROVITZ, ZP

IRONSIDE, JW

NAYLOR, RJ

WILLIAMS, TJ

机构：

[1] SQUIBB INST MED RES,PRINCETON,NJ 08540

[2] UNIV LEEDS,DEPT PATHOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

BRAIN RESEARCH BULLETIN | 1990年 / 25卷 / 01期

关键词：

Angiotensin coverting enzyme; Human temporal cortex; [!sup]3[!/sup]H]SQ29,852;

D O I：

10.1016/0361-9230(90)90273-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The angiotensin coverting enzyme (ACE) inhibitor [3H]SQ29,852 identified a single high affinity recognition site (defined by 10.0 μM captopril) in the human temporal cortex (pKD 8.62 ± 0.03; Bmax 248 ± 24 fmol mg-1 protein, mean±S.E.M., n = 4). ACE inhibitors and thiorphan competed to a similar level for the [3H]SQ29,852 binding site in the human temporal cortex with a rank order of affinity (pKi values mean ± S.E.M., n = 3), lisinopril (9.49 +- 0.02), captopril (9.16 ±0.08), SQ29.852 (8.58 ± 0.04), epicaptopril (7.09 ± 0.08), fosinopril (7.08 ± 0.05) and thiorphan (6.40 ± 0.04). Since this rank order of affinity is similar to the affinity of these compounds to inhibit brain ACE activity it is concluded that [3H]SQ29,852 selectively labels the inhibitor recognition site of ACE in the human temporal cortex. © 1990.

引用

页码：183 / 185

页数：3

共 18 条

[1] ANGIOTENSIN-II INHIBITS ACETYLCHOLINE-RELEASE FROM HUMAN TEMPORAL CORTEX - IMPLICATIONS FOR COGNITION [J].