MOLECULAR ARCHITECTURE AND ELECTROSTATIC PROPERTIES OF A BACTERIAL PORIN

被引：593

作者：

WEISS, MS

ABELE, U

WECKESSER, J

WELTE, W

SCHILTZ, E

SCHULZ, GE ^{[1
]}

机构：

[1] INST ORGAN CHEM & BIOCHEM,ALBERTSTR 21,W-7800 FREIBURG,GERMANY

[2] INST BIOL 2,W-7800 FREIBURG,GERMANY

[3] INST BIOPHYS & STRAHLENBIOL,W-7800 FREIBURG,GERMANY

来源：

SCIENCE | 1991年 / 254卷 / 5038期

关键词：

D O I：

10.1126/science.1721242

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The integral membrane protein porin from Rhodobacter capsulatus consists of three tightly associated 16-stranded beta-barrels that give rise to three distinct diffusion channels for small solutes through the outer membrane. The x-ray structure of this porin has revealed details of its shape, the residue distributions within the pore and at the membrane-facing surface, and the location of calcium sites. The electrostatic potential has been calculated and related to function. Moreover, potential calculations were found to predict the Ca2+ sites.

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页码：1627 / 1630

页数：4

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