MICROBIAL HYDROLYSIS AS A POTENT METHOD FOR THE PREPARATION OF OPTICALLY-ACTIVE NITRILES, AMIDES AND CARBOXYLIC-ACIDS

被引：99

作者：

KAKEYA, H ^{[1
]}

SAKAI, N ^{[1
]}

SUGAI, T ^{[1
]}

OHTA, H ^{[1
]}

机构：

[1] KEIO UNIV,DEPT CHEM,HIYOSHI,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(00)79663-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of alpha-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

引用

页码：1343 / 1346

页数：4

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