ISOLATION AND STRUCTURE DETERMINATION OF PYCNIDIONE, A NOVEL BISTROPOLONE STROMELYSIN INHIBITOR FROM A PHOMA SP

被引：50

作者：

HARRIS, GH ^{[1
]}

HOOGSTEEN, K ^{[1
]}

SILVERMAN, KC ^{[1
]}

RAGHOOBAR, SL ^{[1
]}

BILLS, GF ^{[1
]}

LINGHAM, RB ^{[1
]}

SMITH, JL ^{[1
]}

DOUGHERTY, HW ^{[1
]}

CASCALES, C ^{[1
]}

PELAEZ, F ^{[1
]}

机构：

[1] MERCK SHARP & DOHME ESPANA,E-28027 MADRID,SPAIN

来源：

TETRAHEDRON | 1993年 / 49卷 / 11期

关键词：

D O I：

10.1016/S0040-4020(01)80357-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel bistropolone, pycnidione (1), was isolated by bioassay guided fractionation from fermentations of a Phoma sp.. The structure was determined by spectroscopic methods and single crystal X-ray diffraction.

引用

页码：2139 / 2144

页数：6

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