IN-VITRO EFFECTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR RELEASED FROM MICROSPHERES

被引:42
作者
MITTAL, S [1 ]
COHEN, A [1 ]
MAYSINGER, D [1 ]
机构
[1] MONTREAL GEN HOSP,CTR RES NEUROSCI,RES INST,MONTREAL,PQ H3G 1A4,CANADA
关键词
MICROENCAPSULATION; BDNF; CHITOSAN; PLGA; MESENCEPHALIC DOPAMINERGIC NEURONS; RETINAL GANGLIA; DORSAL ROOT GANGLIA; NEUROTROPHIN DELIVERY;
D O I
10.1097/00001756-199412000-00043
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE principal objective of these studies was to microencapsulate brain derived neurotrophic factor (BDNF) and to test its biological effects in vitro. Two types of microspheres with BDNF were prepared using biodegradable polymers: chitosan and poly-(L-lactic acid):poly-(L-glycolic acid). Depending on the procedure, sizes ranged from 1 mu m to 1 mm as determined by an image analysis system. The biological assays confirmed that the released BDNF remains biologically active in vitro. Microencapsulation of BDNF and other trophic factors may represent a viable alternative to currently employed delivery systems in vivo and holds potential for eventual therapy of neurodegenerative disorders, in particular for peripheral neuropathies and CNS disorders where supplementation of neurotrophins retards or even prevents neural degeneration.
引用
收藏
页码:2577 / 2582
页数:6
相关论文
共 24 条
[1]   BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].
ALDERSON, RF ;
ALTERMAN, AL ;
BARDE, YA ;
LINDSAY, RM .
NEURON, 1990, 5 (03) :297-306
[2]   MONOCLONAL-ANTIBODIES SHOW THAT NEUROFIBRILLARY TANGLES AND NEUROFILAMENTS SHARE ANTIGENIC DETERMINANTS [J].
ANDERTON, BH ;
BREINBURG, D ;
DOWNES, MJ ;
GREEN, PJ ;
TOMLINSON, BE ;
ULRICH, J ;
WOOD, JN ;
KAHN, J .
NATURE, 1982, 298 (5869) :84-86
[3]  
COHEN A, 1994, IN PRESS J NEUROBIOL
[4]   THE NEUROTROPHINS BDNF, NT-3, AND NGF DISPLAY DISTINCT PATTERNS OF RETROGRADE AXONAL-TRANSPORT IN PERIPHERAL AND CENTRAL NEURONS [J].
DISTEFANO, PS ;
FRIEDMAN, B ;
RADZIEJEWSKI, C ;
ALEXANDER, C ;
BOLAND, P ;
SCHICK, CM ;
LINDSAY, RM ;
WIEGAND, SJ .
NEURON, 1992, 8 (05) :983-993
[5]   MOLECULAR-CLONING AND NEUROTROPHIC ACTIVITIES OF A PROTEIN WITH STRUCTURAL SIMILARITIES TO NERVE GROWTH-FACTOR - DEVELOPMENTAL AND TOPOGRAPHICAL EXPRESSION IN THE BRAIN [J].
ERNFORS, P ;
IBANEZ, CF ;
EBENDAL, T ;
OLSON, L ;
PERSSON, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5454-5458
[6]   EFFECTS OF BIOLOGICALLY DELIVERED NGF, BDNF AND BFGF ON STRIATAL EXCITOTOXIC LESIONS [J].
FRIM, DM ;
UHLER, TA ;
SHORT, MP ;
EZZEDINE, ZD ;
KLAGSBRUN, M ;
BREAKEFIELD, XO ;
ISACSON, O .
NEUROREPORT, 1993, 4 (04) :367-370
[7]   BDNF IS A NEUROTROPHIC FACTOR FOR DOPAMINERGIC-NEURONS OF THE SUBSTANTIA-NIGRA [J].
HYMAN, C ;
HOFER, M ;
BARDE, YA ;
JUHASZ, M ;
YANCOPOULOS, GD ;
SQUINTO, SP ;
LINDSAY, RM .
NATURE, 1991, 350 (6315) :230-232
[8]  
JOHNSON JE, 1986, J NEUROSCI, V6, P3031
[9]  
KENIGSBERG RL, 1990, HISTOCHEMISTRY, V95, P155
[10]  
KNUSEL B, 1991, P NATL ACAD SCI USA, V88, P9621