APPLICATION OF EXPERIMENTAL-DESIGN TO THE DEVELOPMENT OF A MULTICOMPONENT DERIVATIVE SPECTROPHOTOMETRIC METHOD - SIMULTANEOUS DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM

被引：30

作者：

ALTESOR, C ^{[1
]}

CORBI, P ^{[1
]}

DOL, I ^{[1
]}

KNOCHEN, M ^{[1
]}

机构：

[1] UNIV REPUBLICA,FAC QUIM,ANAL INSTRUMENTAL LAB,MONTEVIDEO 11800,URUGUAY

来源：

ANALYST | 1993年 / 118卷 / 12期

关键词：

MULTICOMPONENT DERIVATIVE SPECTROPHOTOMETRY; DIODE ARRAY; EXPERIMENTAL DESIGN; SULFAMETHOXAZOLE; TRIMETHOPRIM;

D O I：

10.1039/an9931801549

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A central composite design is used for the development of a spectrophotometric method for the simultaneous determination of sulfamethoxazole and trimethoprim. The method involves multicomponent second-derivative spectrophotometry in the ultraviolet range with a photodiode-array spectrophotometer. Accuracy, precision, linearity and other figures of merit are verified in connection with the application of the proposed method to pharmaceutical quality control. The influence of such variables as wavelength range, derivative order and solvent are discussed.

引用

页码：1549 / 1553

页数：5

共 16 条

[1]

BAYNE CK, 1986, PRACTICAL EXPT DESIG, P150

[2] EFFECTS OF TEMPERATURE-VARIATION ON THE ZERO, 2ND AND 4TH DERIVATIVE ULTRAVIOLET-ABSORPTION SPECTRA OF BENZENOID DRUGS [J].

DAVIDSON, AG .

ANALYST, 1983, 108 (1287) :728-732

[3] THE TEMPERATURE-DEPENDENCE OF DERIVATIVE ULTRAVIOLET-ABSORPTION SPECTRA [J].

DAVIDSON, AG .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1985, 3 (04) :329-334

[4]

ETXEBERRIA J, 1991, PROGRAMACION ANAL ES

[5] DETERMINATION OF CHLORPROMAZINE AND ITS SULFOXIDE IN PHARMACEUTICAL DOSAGE FORMS BY 3RD-ORDER DERIVATIVE ULTRAVIOLET SPECTROSCOPY [J].

FASANMADE, AA ;

FELL, AF .

ANALYST, 1985, 110 (09) :1117-1124

[6] SIMULTANEOUS DETERMINATION OF TRANYLCYPROMINE SULFATE AND TRIFLUOPERAZINE DIHYDROCHLORIDE IN TABLETS BY 1ST-DERIVATIVE AND 4TH-DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRY [J].

KNOCHEN, M ;

ALTESOR, C ;

DOL, I .

ANALYST, 1989, 114 (10) :1303-1305

[7] 1ST DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN DRUGS IN 2-COMPONENT MIXTURES [J].

KORANY, MA ;

WAHBI, AM ;

ELSAYED, MA ;

MANDOUR, S .

ANALYTICAL LETTERS PART B-CLINICAL AND BIOCHEMICAL ANALYSIS, 1984, 17 (12) :1373-1389

[8]

LEVILLAIN P, 1986, ANALUSIS, V14, P1

[9]

MASSART DL, 1988, CHEMOMETRICS TXB, P271

[10] ZERO-CROSSING DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF MIXTURES OF CEPHAPIRIN SODIUM AND CEFUROXIME SODIUM IN PURE FORM AND IN INJECTIONS [J].

MORELLI, B .

ANALYST, 1988, 113 (07) :1077-1082

← 1 2 →