HLA-DR EXPRESSION IN MACAQUE NEUROENDOTHELIAL CELLS-INVITRO AND DURING SIV ENCEPHALITIS

被引：5

作者：

BEILKE, MA ^{[1
]}

IN, DR ^{[1
]}

HAMILTON, R ^{[1
]}

STONE, GA ^{[1
]}

JORDAN, EK ^{[1
]}

BRASHEARS, G ^{[1
]}

NUSBAUM, W ^{[1
]}

HUDDLESTON, D ^{[1
]}

GIBBS, CJ ^{[1
]}

GRAVELL, M ^{[1
]}

机构：

[1] NINCDS,CENT NERVOUS SYST STUDIES LAB,BASIC NEUROSCI PROGRAM,BETHESDA,MD 20892

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 33卷 / 02期

关键词：

ENDOTHELIAL CELL; INTERFERON-GAMMA; HLA-DR; ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN; AUTOIMMUNITY;

D O I：

10.1016/0165-5728(91)90057-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

HLA-DR expression in neuroendothelial cells (NEC) was studied during the course of SIV encephalitis in rhesus monkeys. HLA-DR determinants were detected on NEC in monkeys with SIV encephalitis, but not in control animals. In situ hybridization with an SIV probe indicated that HLA-DR expression was not a consequence of SIV replication within NEC. Cultured rhesus NEC stimulated with gamma interferon expressed HLA-DR to a higher degree than cultured brain fibroblasts or astrocytes. These data support the contention that NEC participate in retrovirus-induced inflammation and autoimmunity within the central nervous system.

引用

页码：129 / 143

页数：15

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