THE INVIVO RELEASE OF Y-90 FROM CYCLIC AND ACYCLIC LIGAND ANTIBODY CONJUGATES

被引：82

作者：

HARRISON, A

WALKER, CA

PARKER, D

JANKOWSKI, KJ

COX, JPL

CRAIG, AS

SANSOM, JM

BEELEY, NRA

BOYCE, RA

CHAPLIN, L

EATON, MAW

FARNSWORTH, APH

MILLAR, K

MILLICAN, AT

RANDALL, AM

RHIND, SK

SECHER, DS

TURNER, A

机构：

[1] UNIV DURHAM, DEPT CHEM, DURHAM DH1 3LE, ENGLAND

[2] CELLTECH LTD, SLOUGH SL1 4EN, ENGLAND

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1991年 / 18卷 / 05期

关键词：

D O I：

10.1016/0883-2897(91)90107-V

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with Y-90 and injected into mice in order to assess the in vivo inertness of the antibody-linked Y-90-ligand complexes. Levels of Y-90 in femur shafts of the DOTA-B72.3 mice were low, being approximately 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DPTA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-Y-90 complex.

引用

页码：469 / 476

页数：8

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