COMPARISON OF SERUM OSTEOCALCIN WITH TOTAL AND BONE SPECIFIC ALKALINE-PHOSPHATASE AND URINARY HYDROXYPROLINE - CREATININE RATIO IN PATIENTS WITH PAGETS-DISEASE OF BONE

被引：11

作者：

KADDAM, IMS ^{[1
]}

IQBAL, SJ ^{[1
]}

HOLLAND, S ^{[1
]}

WONG, M ^{[1
]}

MANNING, D ^{[1
]}

机构：

[1] LEICESTER ROYAL INFIRM,DEPT CHEM PATHOL,LEICESTERSHIRE DIST PATHOL SERV,LEICESTER LE1 5WW,ENGLAND

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1994年 / 31卷

关键词：

BONE GLA PROTEIN; OSTEOBLASTS; MARKERS OF BONE TURNOVER;

D O I：

10.1177/000456329403100403

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Osteocalcin or bone Gla protein (BGP) is secreted by osteoblasts, and its serum concentration is elevated in a number of conditions with high bone turnover. A comparison of serum osteocalcin with total (TALP) and bone specific alkaline phosphatase (BALP) and urinary hydroxyproline/creatinine (OHP/Cr ratio) was performed in 13 patients with active Paget's disease of bone. BGP did not correlate significantly with either BALP or TALP, but did show a significant correlation with OHP/Cr ratio (r = 0.76; P < 0.01). BGP does not appear to be as sensitive a marker as BALP or TALP in Paget's disease.

引用

页码：327 / 330

页数：4

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