INTRACEREBRAL TRANSPLANTS OF PRIMARY MUSCLE-CELLS - A POTENTIAL PLATFORM FOR TRANSGENE EXPRESSION IN THE BRAIN

被引：29

作者：

JIAO, S

SCHULTZ, E

WOLFF, JA

机构：

[1] UNIV WISCONSIN,DEPT PEDIAT & MED GENET,607 WAISMAN CTR,1500 HIGHLAND AVE,MADISON,WI 53706

[2] UNIV WISCONSIN,DEPT ANAT,MADISON,WI 53706

来源：

BRAIN RESEARCH | 1992年 / 575卷 / 01期

关键词：

GENE THERAPY; PRIMARY MYOBLAST; INTRABRAIN TRANSPLANTATION; TRANSGENE; PLASMID DNA; GENE TRANSFER; BRAIN DISEASE; PARKINSONS DISEASE;

D O I：

10.1016/0006-8993(92)90434-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

After the transplantation of rat primary muscle cells into the caudate or cortex of recipient rats, the muscle cells were able to persist for at least 6 months. Muscle cells transfected with expression plasmids prior to transplantation were able to express reporter genes in the brains for at least 2 months. These results suggest that muscle cells might be a useful 'platform' for transgene expression in the brain.

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收藏

页码：143 / 147

页数：5

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