EFFECT OF GLASS CERAMIC AND TITANIUM IMPLANTS ON PRIMARY CALCIFICATION DURING RAT TIBIAL BONE HEALING

被引:27
作者
SCHWARTZ, Z
AMIR, D
BOYAN, BD
COCHAVY, D
MAI, CM
SWAIN, LD
GROSS, U
SELA, J
机构
[1] UNIV TEXAS,HLTH SCI CTR,DEPT ORTHOPAED,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284
[2] UNIV TEXAS,HLTH SCI CTR,DEPT BIOCHEM,SAN ANTONIO,TX 78284
[3] HEBREW UNIV JERUSALEM,DEPT PERIODONT,JERUSALEM,ISRAEL
[4] HEBREW UNIV JERUSALEM,DEPT ORTHOPAED,JERUSALEM,ISRAEL
[5] HEBREW UNIV JERUSALEM,DEPT REHABIL,JERUSALEM,ISRAEL
[6] HEBREW UNIV JERUSALEM,DEPT PATHOL,JERUSALEM,ISRAEL
[7] FREE UNIV BERLIN,DEPT PATHOL,W-1000 BERLIN 33,GERMANY
关键词
IMPLANTS; GLASS CERAMIC; MATRIX VESICLES; BONE HEALING; CALCIFICATION;
D O I
10.1007/BF02556260
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of bone bonding (KG Cera, Mina 13, and titanium) and nonbone bonding (KGy-213, M 8/1) implants on primary calcification in endosteal bone was examined by comparing changes in the morphometry of matrix vesicles to those occurring during normal bone healing following ablation of rat tibial marrow. The concentration of matrix vesicles, their diameter, and their distance from the calcification front were determined using computerized cytomorphometry at the transmission electron microscopic level. The results demonstrated that bone bonding materials supported an increase in matrix vesicle concentration when compared with control bone at 6 and 14 days postimplantation. At 14 days, there were fewer matrix vesicles in the bone adjacent to the nonbonding implants. Though matrix vesicle diameter decreased in the control bone between 6 and 14 days, it increased in all of the experimental samples. Diameters were significantly greater in the bone bonding samples at 14 days and significantly lower in the nonbonding samples at 6 days. Distance from the calcification front decreased between 6 and 14 days in all groups except in bone adjacent to the KGy-213 implants. In bone adjacent to the bone bonding implants, distance from the calcification front was comparable to or further than that of control bone; in the nonbonding samples it was closer to the calcification front. These results demonstrate that production and maturation of matrix vesicles is influenced in a differential manner by the presence of implant materials.
引用
收藏
页码:359 / 364
页数:6
相关论文
共 42 条
[1]  
ALI SY, 1976, FED PROC, V35, P135
[2]   ISOLATION AND CHARACTERIZATION OF CALCIFYING MATRIX VESICLES FROM EPIPHYSEAL CARTILAGE [J].
ALI, SY ;
SAJDERA, SW ;
ANDERSON, HC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 67 (03) :1513-+
[3]   ELECTRON MICROSCOPIC STUDIES OF INDUCED CARTILAGE DEVELOPMENT AND CALCIFICATION [J].
ANDERSON, HC .
JOURNAL OF CELL BIOLOGY, 1967, 35 (01) :81-+
[4]  
ANDERSON HC, 1976, BIOCHEMISTRY PHYSIOL, V4, P135
[5]  
Anderson HC, 1985, BONE MINERAL RES, V3, P109
[6]   CORRELATIVE MORPHOMETRIC AND BIOCHEMICAL-ANALYSIS OF PURIFIED EXTRACELLULAR-MATRIX VESICLES FROM RAT ALVEOLAR BONE [J].
BAB, I ;
DEUTSCH, D ;
SCHWARTZ, Z ;
MUHLRAD, A ;
SELA, J .
CALCIFIED TISSUE INTERNATIONAL, 1983, 35 (03) :320-326
[7]  
BLENCKE B, 1977, T7791 BUND MIN FORSC
[8]   THE EFFECT OF GLASS-CERAMIC BONE IMPLANT MATERIALS ON THE INVITRO FORMATION OF HYDROXYAPATITE [J].
BLUMENTHAL, NC ;
POSNER, AS ;
COSMA, V ;
GROSS, U .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1988, 22 (11) :1033-1041
[9]  
Bonucci E, 1971, Clin Orthop Relat Res, V78, P108, DOI 10.1097/00003086-197107000-00010
[10]   FINE STRUCTURE OF EARLY CARTILAGE CALCIFICATION [J].
BONUCCI, E .
JOURNAL OF ULTRASTRUCTURE RESEARCH, 1967, 20 (1-2) :33-&