COMPARISON OF SINGLE-DOSE ANTITHROMBOTIC AGENTS IN THE PREVENTION OF MICROVASCULAR THROMBOSIS

被引：10

作者：

DAVIDSON, SF ^{[1
]}

BRANTLEY, SK ^{[1
]}

DAS, SK ^{[1
]}

机构：

[1] UNIV MISSISSIPPI,MED CTR,DEPT SURG,DIV PLAST SURG,2500 N STATE ST,JACKSON,MS 39216

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 1991年 / 16A卷 / 04期

关键词：

D O I：

10.1016/0363-5023(91)90177-D

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

A model of thrombosis was used to evaluate the efficacy of single-dose heparin, hemodilution, and 40,000 milliwatts dextran in the prevention of microvascular thrombosis. Forty Lewis rats (275 gm body weight) were divided into four groups (n = 10): hemodilution (6 ml NS), single-dose heparin (1-mu/gm), 40,000 mw dextran (0.3 gm/100 gm), and control (0.275 ml NS). After exposure of the superficial femoral arteries, a model of arterial crush with arteriotomy followed by an intimal abrasion was used. The animals randomly received one of the four solutions above. Experimental results included patency rates of 90% at 20 minutes and 10% at 24 hours in the hemodilution group, 100% at 20 minutes, and 70% at 24 hours in the single-dose heparin group, and 100% at both 20 minutes and 24 hours in the dextran group. A 100% thrombosis rate was observed in the control group at 20 minutes and 24 hours. Single-dose heparin and dextran significantly improved patency in comparison to both the control and hemodilution groups at 24 hours (p less than 0.01). Scanning electron microscopy of the vessels revealed thrombus deposition consistent with these findings. These results indicate that single-dose heparin and single-dose dextran reduce thrombosis in this model of microvascular injury.

引用

页码：585 / 589

页数：5

共 27 条

[1]

Shaw, Converse, A survey of 2680 free flaps: survival, donor site, and applications among experienced microvascular surgeons, Proceedings of the Fiftieth Annual Convention of the American Society of Plastic and Reconstructive Surgery, 4, pp. 93-98, (1987)

[2]

Weiland, Villarreal-Rios, Klein, Kutz, Atasoy, Lister, Replantation of digits and hands: analyses of surgical technique and functional results in 71 patients with 86 replantations, J Hand Surg, 2, pp. 1-9, (1977)

[3]

Reichel, Croll, Puckett, A comparison of irrigation solutions for microanastomoses, The Journal of Hand Surgery, 13 A, pp. 33-36, (1986)

[4]

Sawyer, Staczewski, Pomerance, Lucas, Stoner, Srinivasan, Utility of anticoagulant drugs in vascular thrombosis Electron microscopic and biophysical study, Surgery, 74, pp. 263-273, (1973)

[5]

Elcok, Fredrickson, The effects of heparin on thrombosis at microvenous anastomotic sites, Archives of Otolaryngology - Head and Neck Surgery, 95, pp. 68-71, (1972)

[6]

Rosenbaum, Sundt, Thrombus formation and endothelial alterations in microarterial anastomoses, J Neurosurg, 47, pp. 430-441, (1977)

[7]

Davies, A world survey of anticoagulation practice in clinical microvascular surgery, Br J Plast Surg, 35, pp. 96-99, (1982)

[8]

Hornstra, Vendelmzans-Starrenburg, Induction of experimental arterial occlusive thrombi in rats, Atherosclerosis, 17, pp. 369-382, (1973)

[9]

Henry, Methods for inducing experimental thrombosis, Angiologia, 13, pp. 554-569, (1962)

[10]

Greenberg, Masem, May, Therapeutic value of intravenous heparin in microvascular surgery: an experimental vascular thrombosis study, J Plast Reconstr Surg, 82, pp. 463-470, (1988)

← 1 2 3 →