SIMPLE AND RAPID SCREENING-PROCEDURE FOR 27 NEUROLEPTICS USING HPLC/DAD

被引：23

作者：

TRACQUI, A

KINTZ, P

KREISSIG, P

MANGIN, P

机构：

[1] Institut de Médecine Légale, F-67085, Strasbourg Cedex, 11, rue Humann

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1992年 / 15卷 / 08期

关键词：

D O I：

10.1080/10826079208018294

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A HPLC/DAD method for simultaneous screening of 27 neuroleptics is presented. After single-step liquid-liquid extraction at pH 9.5 using chloroform/2-propanol/n-heptane (60/14/26, v/v), the substances are eluted on a Novapak C18 4-mu-m column, with methanol-tetrahydrofuran/pH 2.6 phosphate buffer (65/5/30, v/v) as the mobile phase. Full UV spectra from 200 to 400 nm are recorded on-line during the entire analysis and may be automatically compared to spectra stored in a library. The method is simple, rapid, reproducible under local conditions, and highly specific.

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收藏

页码：1381 / 1396

页数：16

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