STRATUM-CORNEUM LIPID MORPHOLOGY AND TRANSEPIDERMAL WATER-LOSS IN NORMAL SKIN AND SURFACTANT-INDUCED SCALY SKIN

被引:43
作者
DENDA, M
KOYAMA, J
NAMBA, R
HORII, I
机构
[1] Shiseido Research Center, Yokohama, 1050 Nippa-cho, Kohoku-ku
关键词
INTERCELLULAR LIPIDS; TRANSEPIDERMAL WATER LOSS; BARRIER FUNCTION;
D O I
10.1007/BF00375842
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Stratum corneum lipid morphology was evaluated using attenuated total reflectance infrared spectroscopy (ATR-IR) in normal skin and surfactant-induced scaly skin to evaluate skin barrier function. To evaluate the degree of order of the intercellular lipid alkyl chain conformation, we measured the wavenumbers (frequency shifts) of the symmetrical and asymmetrical C - H stretching vibrations observed at approximately 2850 cm-1 and 2920 cm-1, respectively. There was a correlation between the wave-number and transepidermal water loss in normal skin. However, no difference was observed in surfactant-induced scaly skin from the baseline value in the wavenumbers of the C - H vibrations. These results suggest that in normal skin, lipid morphology plays an important role in the barrier function of the stratum corneum. However, the decline in barrier function in scaly skin is not due to conformational disorder of the lipid alkyl chain.
引用
收藏
页码:41 / 46
页数:6
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