GROWTH HORMONE-RELEASING PEPTIDE-6 STIMULATES SLEEP, GROWTH-HORMONE, ACTH AND CORTISOL RELEASE IN NORMAL MAN

被引：106

作者：

FRIEBOES, RM

MURCK, H

MAIER, P

SCHIER, T

HOLSBOER, F

STEIGER, A

机构：

[1] Max Planck Institute of Psychiatry, Clinical Institute, Department of Psychiatry, Munich

来源：

NEUROENDOCRINOLOGY | 1995年 / 61卷 / 05期

关键词：

GROWTH HORMONE; GROWTH HORMONE RELEASING PEPTIDES; CORTICOTROPINS; ADRENAL STEROIDS; CLINICAL NEUROENDOCRINOLOGY; SLEEP;

D O I：

10.1159/000126883

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The synthetic hexapeptide growth hormone-releasing peptide (GHRP-6) stimulates growth hormone (GH) release in animals and man. GH-releasing hormone (GHRH) has the same effect. In addition, pulsatile administration of GHRH in normal men results in increased slow-wave sleep (SWS) and blunted cortisol levels. The effect of GHRP on nocturnal hormone secretion and on the sleep electroencephalogram (EEG) is still unknown. We compared the effect of repetitive i.v. boluses (4 x 50 mu g) of GHRP and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of GH, ACTH and cortisol (20.00 to 07.00 h) in normal male controls. After GHRP, the GH concentration (22.00 to 03.00 h) increased(15.4 +/- 9.6 ng/ml after GHRP vs. 5.5 +/- 4.0 ng/ml after FL, p < 0.02), as did the ACTH level (22.00 to 02.00 h: 21.0 +/- 5.3 pg/ml after GHRP vs. 16.6 +/- 3.1 pg/ml after FL, p < 0.02). During the total night, and particularly during the first half of the night, cortisol secretion was enhanced (22.00 to 03.00 h: 56.0 +/- 31.0 ng/ml after GHRP vs. 25.2 +/- 9.0 ng/ml after FL, p < 0.02). Stage 2 sleep increased (270.1 +/- 25.3 min after GHRP vs. 245.4 +/- 25.8 min after FL, p < 0.02), whereas other sleep-EEG variables including SWS remained unchanged. Our data demonstrate that GHRP stimulates not only GH release but also hypothalamic-pituitary-adrenocortical hormone secretion. The latter effect is opposite to the blunting of cortisol after GHRH. Both GHRP and GHRH promote sleep. However, GHRP enhances stage 2 sleep and does not affect SWS. The different actions of GHRP and GHRH are a further indication that they act at different receptors.

引用

页码：584 / 589

页数：6

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