VITAMIN-E SUCCINATE POTENTIATES THE INHIBITORY EFFECT OF PROSTAGLANDINS ON ORAL SQUAMOUS CARCINOMA CELL-PROLIFERATION

被引:14
作者
ELATTAR, TMA [1 ]
LIN, HS [1 ]
机构
[1] UNIV MISSOURI, SCH MED, HORMONE RES LAB, KANSAS CITY, MO 64108 USA
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1995年 / 52卷 / 01期
关键词
D O I
10.1016/0952-3278(95)90099-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Previous studies have shown that prostaglandin E(2) (PGE(2)) and vitamin E succinate can act in an additive manner to inhibit the proliferation of human oral squamous carcinoma cells (SCC-25), The initial studies on the additive anticancer activity of PGE(2) and vitamin E succinate have been extended to include antineoplastic PGs, Delta(12)-PGJ(2) and PGJ(2). Treatment of oral squamous carcinoma cells (SCC-15) with Delta(12)-PGJ(2), PGJ(2), and vitamin E succinate, individually, caused significant concentration-dependent inhibition of cell proliferation to various degrees, PGJ(2) was most potent and caused an inhibition that corresponded to 85.55% at 10(-5) M. Addition of 1 mu M of vitamin E succinate to Delta(12)-PGJ(2) or PGJ(2) resulted in a significant increase in the inhibitory potency of the lower concentrations of the two PGs. These results suggest a novel role for a mixture of PGs and vitamin E as potent antitumor proliferative agents.
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页码:69 / 73
页数:5
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