ANTIBACTERIAL SYNERGISM - PROPOSAL FOR CHEMOTHERAPEUTIC POTENTIATION BETWEEN TRIMETHOPRIM AND SULFAMETHOXAZOLE

被引：56

作者：

POE, M ^{[1
]}

机构：

[1] MERCK INST THERAPEUTIC RES, RAHWAY, NJ 07065 USA

来源：

SCIENCE | 1976年 / 194卷 / 4264期

关键词：

D O I：

10.1126/science.788154

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sulfamethoxazole and other sulfa drugs are moderately potent inhibitors of Escherichia coli dihydrofolate reductase. They also significantly potentiate the inhibition of this enzyme by trimethoprim. The molecular basis for inhibition potentiation is the simultaneous binding of trimethoprim and sulfa by the enzyme. This potentiation may explain the synergism observed when these drugs are used in antibacterial chemotherapy.

引用

页码：533 / 535

页数：3

共 25 条

[1] ABSORPTION AND URINARY EXCRETION OF TRIMETHOPRIM, SULFAMETHOXAZOLE, AND TRIMETHOPRIM-SULFAMETHOXAZOLE - RESULTS WITH SINGLE DOSES IN NORMAL YOUNG-ADULTS AND PRELIMINARY OBSERVATIONS DURING THERAPY WITH TRIMETHOPRIM-SULFAMETHOXAZOLE [J].