THE DROSOPHILA DUNCE LOCUS - LEARNING AND MEMORY GENES IN THE FLY

被引：29

作者：

DAVIS, RL ^{[1
]}

DAUWALDER, B ^{[1
]}

机构：

[1] BAYLOR UNIV,DIV NEUROSCI,HOUSTON,TX 77030

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0168-9525(91)90369-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The dunce gene, one of several genes critical for normal learning and memory in Drosophila, is organized in a complex and bizarre way, with enormous introns containing several other unrelated genes. Recent studies have focused on the spatial expression pattern of the product, cAMP phosphodiesterase, and have provisionally identified the mushroom bodies as important sites of action of dunce within adult brain. In addition, the recent cloning and characterization of dunce counterparts from mammals has revealed that these too may participate in animal behavior and, in particular, in the regulation of mood.

引用

收藏

页码：224 / 229

页数：6

相关论文

共 40 条

[31] THE CYCLIC-AMP PHOSPHODIESTERASE ENCODED BY THE DROSOPHILA DUNCE GENE IS CONCENTRATED IN THE MUSHROOM BODY NEUROPIL [J].

NIGHORN, A ;

HEALY, MJ ;

DAVIS, RL .

NEURON, 1991, 6 (03) :455-467

[32] CONDITIONED BEHAVIOR IN DROSOPHILA-MELANOGASTER [J].

QUINN, WG ;

HARRIS, WA ;

BENZER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (03) :708-712

[33]

SCHWARZ TL, 1990, NEURON, V2, P119

[34] MOLECULAR-CLONING OF RAT HOMOLOGS OF THE DROSOPHILA-MELANOGASTER DUNCE CAMP PHOSPHODIESTERASE - EVIDENCE FOR A FAMILY OF GENES [J].

SWINNEN, JV ;

JOSEPH, DR ;

CONTI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) :5325-5329

[35] REWARD LEARNING IN NORMAL AND MUTANT DROSOPHILA [J].

TEMPEL, BL ;

BONINI, N ;

DAWSON, DR ;

QUINN, WG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (05) :1482-1486

[36] CLASSICAL-CONDITIONING AND RETENTION IN NORMAL AND MUTANT DROSOPHILA-MELANOGASTER [J].

TULLY, T ;

QUINN, WG .

JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 1985, 157 (02) :263-277

[37] DROSOPHILA LEARNING AND MEMORY REVISITED [J].

TULLY, T .

TRENDS IN NEUROSCIENCES, 1987, 10 (08) :330-335

[38] LEVELS OF RNA FROM A FAMILY OF PUTATIVE SERINE PROTEASE GENES ARE REDUCED IN DROSOPHILA-MELANOGASTER DUNCE MUTANTS AND ARE REGULATED BY CYCLIC-AMP [J].

YUN, YD ;

DAVIS, RL .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (02) :692-700

[39] COPIA RNA LEVELS ARE ELEVATED IN DUNCE MUTANTS AND MODULATED BY CAMP [J].

YUN, YD ;

DAVIS, RL .

NUCLEIC ACIDS RESEARCH, 1989, 17 (20) :8313-8326

[40] ALTERED SYNAPTIC PLASTICITY IN DROSOPHILA MEMORY MUTANTS WITH A DEFECTIVE CYCLIC-AMP CASCADE [J].

ZHONG, Y ;

WU, CF .

SCIENCE, 1991, 251 (4990) :198-201

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