MAGNESIUM SELECTIVELY INHIBITS N-METHYL-ASPARTIC ACID-INDUCED HYPERMOTILITY AFTER INTRA-ACCUMBENS INJECTION

被引：11

作者：

DONZANTI, BA ^{[1
]}

URETSKY, NJ ^{[1
]}

机构：

[1] OHIO STATE UNIV, COLL PHARM, DEPT PHARMACOL, COLUMBUS, OH 43210 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1984年 / 20卷 / 02期

关键词：

D O I：

10.1016/0091-3057(84)90249-1

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The excitatory amino acids, N-methyl-aspartic acid, kainic acid and quisqualic acid produce a marked increase in locomotor activity after bilateral injection into the rat nucleus accumbens. The intra-accumbens injection of Mg inhibited the hypermotility response produced by N-methyl-aspartic acid in a dose-dependent manner. Mg had no significant inhibitory effect on the increase in motility produced by either kainic acid or quisqualic acid. Ca produced a weak inhibitory action on N-methyl-aspartic acid-induced hypermotility. In the nucleus accumbens, at least 2 receptor types (N-methyl-aspartic acid Mg-sensitive and non-N-methyl-aspartic acid/Mg-insensitive receptors) are present which can mediate the stimulation of locomotor activity produced by excitatory amino acids.

引用

页码：243 / 246

页数：4

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