MINOR HISTOCOMPATIBILITY ANTIGENS

被引：21

作者：

LINDAHL, KF ^{[1
]}

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT BIOCHEM, DALLAS, TX 75235 USA

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 07期

关键词：

D O I：

10.1016/0168-9525(91)90368-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Histocompatibility antigens have been studied for over 50 years because they form a major obstacle to clinical transplantation. Human minor histocompatibility antigens remain ill-defined, but minor histocompatibility loci have been mapped on nearly every mouse chromosome. Recent molecular definition of several transplantation antigens suggests that they are by-products of an immune system poised to present viral antigens, and a mutation in any gene may give rise to a new minor histocompatibility antigen.

引用

页码：219 / 224

页数：6

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