HYPOLIPIDEMIC EFFECTS OF NB-598 IN DOGS

被引：26

作者：

HORIE, M

SAWASAKI, Y

FUKUZUMI, H

WATANABE, K

IIZUKA, Y

TSUCHIYA, Y

KAMEI, T

机构：

[1] Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Meguro-ku, Tokyo, 153, 2-9-3, Shimomeguro

来源：

ATHEROSCLEROSIS | 1991年 / 88卷 / 2-3期

关键词：

NB-598; HYPOLIPIDEMIC DRUG; SQUALENE EPOXIDASE INHIBITOR; SQUALENE; CHOLESTEROL; BILE ACIDS; LIPOPROTEIN; DOG;

D O I：

10.1016/0021-9150(91)90080-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

NB-598, a new inhibitor of mammalian squalene epoxidase, was found to be a potent inhibitor of microsomal squalene epoxidase from dog liver. Hypolipidemic effects of NB-598 were compared with those of simvastatin (MK-733, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor) in dogs. NB-598 was found to decrease serum total cholesterol levels and increase serum squalene levels in a dose-dependent manner. MK-733 decreased serum total cholesterol and squalene levels. Both NB-598 and MK-733 decreased all classes of lipoprotein cholesterol, and they decreased low density lipoprotein cholesterol most potently. Both drugs decreased phospholipid levels in parallel with cholesterol levels. NB-598 also decreased triacylglycerol levels. After termination of drug administration, these levels returned to the control levels. The potency of NB-598 is thought to be as great or greater than that of MK-733. Moreover, NB-598 increased squalene concentrations in the feces and gallbladder bile, but it did not affect neutral sterol and bile acid concentrations. NB-598 did not affect the lithogenic index.

引用

页码：183 / 192

页数：10

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