SYNTHESIS OF 3'-ETHYNYLTHYMIDINE,3'-VINYLTHYMIDINE AND 3'-BROMOVINYLTHYMIDINE AS POTENTIAL ANTIVIRAL AGENTS

被引：21

作者：

SAHLBERG, C

机构：

[1] Medivir AB, S-141 44 Huddinge

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)92341-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of three novel 3'-unsaturated carbon analogues of AZT and FLT is described. The key step in the synthesis is a Cu(I)- catalyzed addition of vinylmagnesium bromide to a 2,3-unsaturated lactone, followed by, in the case of compounds 2 and 3, elimination reactions of a dibromo-compound.

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页码：679 / 682

页数：4

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