EXPRESSION OF 25(OH) VITAMIN-D-3 24-HYDROXYLASE GENE IN GLIAL-CELLS

被引：52

作者：

NAVEILHAN, P ^{[1
]}

NEVEU, I ^{[1
]}

BAUDET, C ^{[1
]}

OHYAMA, KY ^{[1
]}

BRACHET, P ^{[1
]}

WION, D ^{[1
]}

机构：

[1] FAC SCI HIROSHIMA,DEPT GENE SCI,HIROSHIMA,HIROSHIMA,JAPAN

来源：

NEUROREPORT | 1993年 / 5卷 / 03期

关键词：

25(OH) 24-HYDROXYLASE; GLIAL CELLS; 1,25(OH)(2); VITAMIN-D-3; BRAIN;

D O I：

10.1097/00001756-199312000-00018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

THE expression of the 25(OH) vitamin D-3 24-hydroxylase gene was studied in C6 glioma and rat primary glial cell culture. The expression of the 25(OH)D-3 24-hydroxylase gene was not detected in C6 glioma or glial cells cultured in a serum-free medium. However, the 25(OH)D-3 24-hydroxylase mRNA was induced in a dose-dependent manner in cells treated with 1,25(OH)(2)D-3. These findings provide further evidence for an involvement of vitamin D-3 metabolites in brain function.

引用

页码：255 / 257

页数：3

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