THE PRIMITIVE METAZOAN HYDRA EXPRESSES ANTISTASIN, A SERINE PROTEASE INHIBITOR OF VERTEBRATE BLOOD-COAGULATION - CDNA CLONING, CELLULAR-LOCALIZATION AND DEVELOPMENTAL REGULATION

被引：30

作者：

HOLSTEIN, TW

MALA, C

KURZ, E

BAUER, K

GREBER, M

DAVID, CN

机构：

[1] Zoologisches Institut, Universität München, 8000 Munich 2

来源：

FEBS LETTERS | 1992年 / 309卷 / 03期

关键词：

ANTISTASIN; SERINE PROTEASE INHIBITOR; FACTOR-XA; BLOOD COAGULATION; HYDRA;

D O I：

10.1016/0014-5793(92)80791-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated and characterized cDNAs from Hydra which encode antistasin, a potent inhibitor of factor Xa in the vertebrate blood clotting cascade. Hydra antistasin is expressed in gland cells and represents a major class of transcripts from Hydra's head. Sequence analysis revealed that Hydra antistasin contains 6 internal repeats of a 25-26 amino acid sequence with a highly conserved pattern of 6 cysteine and 2 glycine residues identical to that in leech antistasin. Conservation of antistasin in a lower metazoan provides a potential link between the vertebrate and invertebrate coagulation systems.

引用

页码：288 / 292

页数：5

共 31 条

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