INSULIN PROPHYLAXIS IN INDIVIDUALS AT HIGH-RISK OF TYPE-I DIABETES

被引：294

作者：

KELLER, RJ

EISENBARTH, GS

JACKSON, RA

机构：

[1] JOSLIN DIABET CTR,BOSTON,MA

[2] BRIGHAM & WOMENS HOSP,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[4] BARBARA DAVIS CTR CHILDHOOD DIABET,DENVER,CO

来源：

LANCET | 1993年 / 341卷 / 8850期

关键词：

D O I：

10.1016/0140-6736(93)91215-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prevention of type I diabetes is now a practical goal thanks to the ability to define confidently a high-risk group and the success of preventive strategies in animal models. We describe here a pilot trial of low-dose insulin to prevent diabetes in relatives of patients with type I diabetes.

引用

页码：927 / 928

页数：2

共 9 条

[1] APPEL MC, 1989, DIABETOLOGIA, V32, pA461
[2] INSULITIS AND DIABETES IN NOD MICE REDUCED BY PROPHYLACTIC INSULIN THERAPY
ATKINSON, MA
MACLAREN, NK
LUCHETTA, R
[J]. DIABETES, 1990, 39 (08) : 933 - 937
[3] REDUCTION OF DIABETES INCIDENCE OF BB WISTAR RATS BY EARLY PROPHYLACTIC INSULIN-TREATMENT OF DIABETES-PRONE ANIMALS
GOTFREDSEN, CF
BUSCHARD, K
FRANDSEN, EK
[J]. DIABETOLOGIA, 1985, 28 (12) : 933 - 935
[4] JACKSON R, 1988, CLIN RES, V36, pA585
[5] INTERACTION OF BETA-CELL ACTIVITY AND IL-1 CONCENTRATION AND EXPOSURE TIME IN ISOLATED RAT ISLETS OF LANGERHANS
PALMER, JP
HELQVIST, S
SPINAS, GA
MOLVIG, J
MANDRUPPOULSEN, T
ANDERSEN, HU
NERUP, J
[J]. DIABETES, 1989, 38 (10) : 1211 - 1216
[6] SHAN SC, 1989, NEW ENGL J MED, V320, P550
[7] COMPETITIVE INSULIN AUTOANTIBODY ASSAY - PROSPECTIVE EVALUATION OF SUBJECTS AT HIGH-RISK FOR DEVELOPMENT OF TYPE-1 DIABETES-MELLITUS
VARDI, P
DIB, SA
TUTTLEMAN, M
CONNELLY, JE
GRINBERGS, M
RADIZABEH, A
RILEY, WJ
MACLAREN, NK
EISENBARTH, GS
SOELDNER, JS
[J]. DIABETES, 1987, 36 (11) : 1286 - 1291
[8] PREDICTING TYPE-1 DIABETES
ZIEGLER, AG
HERSKOWITZ, RD
JACKSON, RA
SOELDNER, JS
EISENBARTH, GS
[J]. DIABETES CARE, 1990, 13 (07) : 762 - 775
[9] 1992, LANCET, V339, P1512

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